2020

Immunology & Cancer

Visualizing tumour self-homing with magnetic particle imaging.

Katie M Parkins, Kierstin P Melo, John A Ronald, Paula J Foster; bioRxiv 2020.02.17.953232;

doi: https://doi.org/10.1101/2020.02.17.953232

Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging

Paysen Hendrik; Loewa Norbert; Stach Anke; Wells, James; Kosch Olaf; et al.Scientific Reports (Nature Publisher Group); London Vol. 10, Iss. 1,  (Feb 2020).

DOI:10.1038/s41598-020-58853-3

Magnetic Particle Imaging of Macrophages Associated with Cancer: Filling the Voids Left by Iron-Based Magnetic Resonance Imaging.

Mol Imaging Biol (2020). Makela, A.V., Gaudet, J.M., Schott, M.A. et al.

https://doi.org/10.1007/s11307-020-01473-0

Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer.

Huijuan You, Wenting Shang, Xiangde Min, Jeffrey Weinreb, Qiubai Li, Michael Leapman, Liang Wang, and Jie Tian. Science Advances  05 Feb 2020: Vol. 6, no. 6, eaax6040

DOI: 10.1126/sciadv.aax6040

Trimodal Cell Tracking In Vivo: Combining Iron- and Fluorine-Based Magnetic Resonance Imaging with Magnetic Particle Imaging to Monitor the Delivery of Mesenchymal Stem Cells and the Ensuing Inflammation.

Olivia C. Sehl, Ashley V. Makela, Amanda M. Hamilton, and Paula J. Foster Tomography. 2019 Dec; 5(4): 367–376.

doi: 10.18383/j.tom.2019.00020

Theranostics and Drug Delivery

Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications

Chandrasekharan P, Tay ZW, Hensley D, et al. Theranostics. 2020;10(7):2965–2981. Published 2020 Feb 10. doi:10.7150/thno.40858

Versatile iron cobalt nanoparticles for theranostics.

Perez, J.E., Van de Walle, A. & Wilhelm, C. Nat Biomed Eng 4, 252–253 (2020).

https://doi.org/10.1038/s41551-020-0532-y

Magnetic particle imaging performance of liposomes encapsulating iron oxide nanoparticles

N.C.V.Rost, K.Sen, S.Savliwala, I.Singh, S.Liu, M.Unni, L.Raniero, C.Rinaldi; Journal of Magnetism and Magnetic Materials Volume 504, 15 June 2020, 166675

Nanoparticle Tracer Development

Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

Lucy Gloag, et.al., Chem. Commun., 2020,56, 3504-3507

Complex Relationship Between Signal Intensity Properties in Magnetic Particle Imaging (MPI) and Iron Oxide Nanoparticle Degradation.
Guzy, Julia; Chakravarty, Shatadru; Buchanan, Foster; Chen, Haoran; M. Gaudet,
Jeffrey; Hix, Jeremy; et al. (2020): ChemRxiv. Preprint.

https://doi.org/10.26434/chemrxiv.11845584.v1

Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties.
Song, G., Kenney, M., Chen, Y. et al. Nat Biomed Eng 4, 325–334 (2020).

https://doi.org/10.1038/s41551-019-0506-0

Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking.
Qiyue Wang, Xibo Ma, Hongwei Liao, Zeyu Liang, Fangyuan Li, Jie Tian, Daishun Ling,
ACS Nano 2020, 14, 2, 2053-2062 https://doi.org/10.1021/acsnano.9b08660

2019

•  
• Magnetic Nanoparticles in Macrophages and Cancer Cells Exhibit Different Signal Behavior on Magnetic Particle Imaging.
  H Suzuka, A Mimura, Y Inaoka, K Murase.
  J Nanosci Nanotechnol. 2019 Nov 1;19(11):6857-6865. doi:10.1166/jnn.2019.16619.
•  
• Magnetic Particle Imaging: Current Applications in Biomedical Research.
  N Taleboo, M Gudi, N Robertson, P Wang.
  JMRI. 2019 Jul 22. doi:10.1002/jmri.26875.
•  
• Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy.
  Y Du, X Liu, Q Liang, XJ Liang, J Tian.
  Nano Lett. 2019 Jun 12;19(6):3618-3626. doi:10.1021/acs.nanolett.9b00630.
•  
• Ferumoxytol can be used for Quantitative Magnetic Particle Imaging of transplanted stem cells.
  H Nejadnik, P Pandit, O Lenkov, AP Lahiji, K Yerneni, HE Daldrup-Link.
  Mol Imaging Biol. 2019 Jun;21(3):465-472. doi:10.1007/s11307-018-1276-x.
•  
• Magnetic Particle Imaging.
  R Thompson.
  Radiol Technol. 2019 May;90(5):520-525.
•  
• Dynamic magnetic characterization and magnetic particle imaging enchancement of magnetic-gold core-shell nanoparticles.
  A Tomitaka, S Ota, K Nishimoto, H Arami, Y Takemura, M Nair.
  Nanoscale. 2019 Mar 28;11(13):6489-6496. doi:10.1039/c9nr00242a.
•  
• Pulsed Excitation in Magnetic Particle Imaging.
  ZW Tay, DW Hensley, J Ma, P Chandrasekharan, B Zheng, PW Goodwill, SM Conolly.
  IEEE Trans Med Imaging. 2019 Feb 11. doi:10.1109/TMI.2019.2898202.
•  
• Magnetic Particle Imaging (MPI) in Neurosurgery.
  A Meola, J Rao, N Chaudhary, G Song, X Zheng, SD Chang.
  World Neurosurg. 2019 Feb 7. pii: S1878-8750(19)30291-8. doi:10.1016/j.wneu.2019.01.180.
•  
• A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging.
  LC Wu, Y Zhang, G Steinberg, H Qu, S Huang, M Cheng, T Bliss, F Du, J Rao, G Song, L Pisani, T Doyle.
  AJNR Am J Neuroradiol. 2019 Feb;40(2):206-212. doi:10.3174/ajnr.A5896.
•  
• Image-Guided Thermal Therapy Using Magnetic Particle Imaging and Magnetic Fluid Hyperthermia.
  R Dhavalikar, AC Bohorquez, C Rinaldi.
  Micro and Nano Technologies. 2019 Jan 1;265-286. https://doi.org/10.1016/B978-0-12-813928-8.00010-7.
•  
• Superparamagnetic iron oxides as MPI tracers: A primer and review of early applications.
  JWM Bulte.
  Adv Drug Deliv Rev. 2019 Jan 1;138:293-301. doi:10.1016/j.addr.2018.12.007

2018

•  
• A perspective on rapid and radiation-free tracer imaging modality, magnetic particle imaging, with promise for clinical translation.
  P Chandrasekharan, ZW Tay, XY Zhou, E Yu, R Orendorff, DW Hensley, Q Huynh, KLB Fung, CC VanHook, PW Goodwill, B Zheng, SM Conolly.
  Br J Radiol. 2018 Nov;91(1091):20180326. doi:10.1259/bjr.20180326.
•  
• Development and MPI tracking of novel hypoxia-targeted theranostic exosomes.
  KO Jung, H Jo, JH Yu, SS Gambhir, G Pratx.
  Biomaterials. 2018 Sep;177:139-148. doi:10.1016/j.biomaterials.2018.05.048.
•  
• Magnetic Particle Imaging Guided heating in vivo using gradient fields for arbitrary localization of magnetic hyperthermia therapy.
  ZW Tay, P Chandrasekharan, A Chiu-Lam, DW Hensley, R Dhavalikar, XY Zhou, E Yu, PW Goodwill, B Zheng, C Rinaldi, SM Conolly.
  ACS Nano. 2018 Apr 24;12(4):3699-3713. doi: 10.1021/acsnano.8b00893.
•  
• The development of a trimodal contrast agent for acoustic and magnetic particle imaging of stem cells.
  JE Lemaster, F Chen, T Kim, A Hariri, JV Jokerst.
  ACS Applied Nano Materials. 2018 Mar 2;1(3):1321-1331. doi:10.1021/acsanm.8b00063.
•  
• Magnetic Particle Imaging of islet transplantation in the liver and under the kidney capsule in mouse models.
  P Wang, PW Goodwill, P Pandit, J Gaudet, A Ross, J Wang, E Yu, DW Hensley, TC Doyle, CH Contag, SM Conolly, A Moore.
  Quant Imaging Med Surg. 2018 Mar;8(2):114-122. doi:10.21037/qims.2018.02.06.
•  
• Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging.
  G Song, M Chen, Y Zhang, L Cui, H Qu, X Zheng, M Wintermark, Z Liu, J Rao.
  Nano Lett. 2018 Jan 10;18(1):182-189. doi: 10.1021/acs.nanolett.7b03829.
•  
• Chapter 5 – Magnetic Particle Imaging (MPI).
  S Zanganeh, M Aieneravaie, M Erfanzadeh, JQ Ho, R Spitler.
  Iron Oxide Nanoparticles for Biomed Applications. 2018 Jan 1;115-133. doi:10.1016/B978-0-08-101925-2.00004-8.

2017

•  
• Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model.
  E Yu, P Chandrasekharan, R Berzon, ZW Tay, XY Zhou, AP Khandhar, RM Ferguson, SJ Kemp, B Zheng, PW Goodwill, MF Wendland, KM Krishnan.
  ACS Nano. 2017 Dec 26;11(12):12067-12076. doi:10.1021/acsnano.7b04844.
•  
• Hybrid magneto-plasmonic liposomes for multimodal image-guided and brain-targeted HIV treatment.
  A Tomitaka, H Arami, Z Huang, A Raymond, E Rodriguez, Y cai, M Febo, Y Takemura, M Nair.
  Nanoscale. 2017 Dec 21;10(1):184-194. doi:10.1039/c7nr07255d.
•  
• Tomographic magnetic particle imaging of cancer targeted nanoparticles.
  H Arami, E Teema, A Troska, H Bradshaw, K Saatchi, A Tomitaka, SS Gambhir, OU Häfeli, D Liggitt, KM Krishnan.
  Nanoscale. 2017 Dec 7;9(47):18723-18730. doi:10.1039/c7nr05502a.
•  
• Multi-channel Acquisition for Isotropic Resolution in Magnetic Particle Imaging.
  K Lu, PW Goodwill, B Zheng, SM Conolly.
  IEEE Trans Med Imaging. 2018 Sep;37(9):1989-1998. doi:10.1109/TMI.2017.2787500.
•  
• Calibration-Free Relaxation-Based Multi-Color Magnetic Particle Imaging.
  Y Muslu, M Utkur, OB Demirel, EU Saritas.
  IEEE Trans Med Imaging. 2018 Aug;37(8):1920-1931. doi:10.1109/TMI.2018.2818261.
•  
• Design analysis of an MPI human functional brain scanner.
  EE Mason, CZ Cooley, SF Cauley, MA Griswald, SM Conolly, LL Wald.
  Int J Magn Part Imaging. 2017;3(1). doi:10.18416/ijmpi.2017.1703008.
•  
• The Relaxation Wall: Experimental Limits to Improving MPI Spatial Resolution by Increasing Nanoparticle Core Size.
  ZW Tay, DW Hensley, EC Vreeland, B Zheng, SM Conolly.
  Biomed Phys Eng Express. 2017 Jun;3(3). doi:10.1088/2057-1976/aa6ab6.
•  
• Seeing SPIOs Directly In Vivo with Magnetic Particle Imaging.
  B Zheng, E Yu, R Orrendorff, K Lu, J Konkle, ZW Tay, DW Hensley, XY Zhou, P Chandrasekharan, EU Saritas, PW Goodwill, JD Hazle.
  Mol Imaging Biol. 2017 Jun;19(3):385-390. doi:10.1007/s11307-017-1081-y.
•  
• Relaxation-based viscosity mapping for magnetic particle imaging.
  M Utkur, Y Muslu, EU Saritas. Phys Med Biol.
  2017 May 7;62(9):3422-3439. doi:10.1088/1361-6560/62/9/3422.
•  
• Combining magnetic particle imaging and magnetic fluid hyperthermia in a theranostic platform.
  DW Hensley, ZW Tay, R Dhavalikar, B Zheng, PW Goodwill, C Rinaldi, SM Conolly.
  Phys Med Biol. 2017 May 7;62(9):3483-3500. doi:10.1088/1361-6560/aa5601.
•  
• Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging.
  P Keselman, E Yu, XY Zhou, PW Goodwill, P Chandrasekharan, RM Ferguson, AP Khandhar, SJ Kemp, KM Krishnan, B Zheng, SM Conolly.
  Phys Med Biol. 2017 May 7;62(9):3440-3453. doi:10.1088/1361-6560/aa5f48.
•  
• First in vivo magnetic particle imaging of lung perfusion in rats.
  XY Zhou, KE Jeffris, E Yu, B Zheng, PW Goodwill, P Nahid, SM Conolly.
  Phys Med Biol. 2017 May 7;62(9):3510-3522. doi:10.1088/1361-6560/aa616c.
•  
• First in vivo traumatic brain injury imaging via magnetic particle imaging.
  R Orendorff, AJ Peck, B Zheng, SN Shirazi, RM Ferguson, AP Khandhar, SJ Kemp, PW Goodwill, KM Krishnan, GA Brooks, D Kaufer, SM Conolly. Phys
• Med Biol.
  2017 May 7;62(9):3501-3509. doi:10.1088/1361-6560/aa52ad.
•  
• Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection.
  E Yu, M Bishop, B Zheng, RM Ferguson, AP Khandhar, SJ Kemp, KM Krishnan, PW Goodwill, SM Connolly. Nano Lett.
  2017 Mar 8;17(3):1648-1654. doi:10.1021/acs.nanolett.6b04865.
•  
• Evaluation of PEG-coated iron oxide nanoparticles as blood pool tracers for preclinical magnetic particle imaging.
  AP Khandhar, P Keselman, SJ Kemp, RM Ferguson, PW Goodwill, SM Conolly, KM Krishnan.
  Nanoscale. 2017 Jan 19;9(3):1299-1306. doi:10.1039/c6nr08468k.

2016

•  
• A High-Throughput, Arbitrary-Waveform, MPI Spectrometer and Relaxometer for Comprehensive Magnetic Particle Optimization and Characterization.
  ZW Tay, PW Goodwill, DW Hensley, LA Taylor, B Zheng, SM Conolly.
  Sci Rep. 2016 Sep 30;6:34180. doi:10.1038/srep34180.
•  
• Finite magnetic relaxation in x-space magnetic particle imaging: Comparison of measurements and ferrohydrodynamic models.
  R Dhavalikar, DW Hensley, L Maldonado-Camargo, LR Croft, S Ceron, PW Goodwill, SM Conolly, C Rinaldi.
  J Phys D Appl Phys. 2016 Aug 3;49(30). doi:10.1088/0022-3727/49/30/305002.
•  
• Eddy current-shielded x-space relaxometer for sensitive magnetic nanoparticle characterization.
  LM Bauer, DW Hensley, B Zheng, ZW Tay, PW Goodwill, MA Griswald,SM Conolly.
  Rev Sci Instrum. 2016 May;87(5):055109. doi:10.1063/1.4950779.
•  
• High-performance iron oxide nanoparticles for magnetic particle imaging – guided hyperthermia (hMPI).
  LM Bauer, SF Situ, MA Griswold, AC Samia.
  Nanoscale. 2016 Jun 16;8(24):12162-9. doi:10.1039/c6nr01877g.
•  
• Low drive field amplitude for improved image resolution in magnetic particle imaging.
  LR Croft, PW Goodwill, J Konkle, H Arami, DA Price, AX Li, EU Saritas, SM Conolly.
  Med Phys. 2016 Jan;43(1):424. doi:10.1118/1.4938097.
•  
• Magnetic nanoparticles: material engineering and emerging applications in lithography and biomedicine.
  Y Bao, T Wen, AC Samia, A Khandhar, KM Krishnan.
  J Mater Sci. 2016 Jan;51(1):513-553. doi:10.1007/s10853-015-9324-2.
•  
• Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo.
  B Zheng, MP von See, E Yu, B Gune, lK Lu, T Vazin, DV Schaffer, PW Goodwill, SM Connolly.
  Theranostics. 2016 Jan 1;6(3):291-301. doi:10.7150/thno.13728.

2015

•  
• Lactoferrin conjugated iron oxide nanoparticles for targeting brain glioma cells in magnetic particle imaging.
  A Tomitaka, H Arami, S Gandhi, KM Krishnan.
  Nanoscale. 2015 Oct 28;7(40):16890-8. doi:10.1039/c5nr02831k.
•  
• A Convex Formulation for Magnetic Particle Imaging X-Space Reconstruction.
  J Konkle, PW Goodwill, DW Hensley, R Orrendorff, M Lustig, SM Conolly.
  PLoS One. 2015 Oct 23;10(10):e0140137. doi:10.1371/journal.pone.0140137.
•  
• Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast.
  B Zheng, T Vazin, PW Goodwill, A Conway, A Verma, EU Saritas, D Schaffer, SM Conolly.
  Sci Rep. 2015 Sep 11;5:14055. doi:10.1038/srep14055.
•  
• Magnetic Particle Imaging Tracers: State-of-the-Art and Future Directions.
  LM Bauer, SF Situ, MA Griswold.
  J Phys Chem Lett. 2015 Jul 2;6(13):2509-17. doi:10.1021/acs.jpclett.5b00610.
•  
• Effects of pulse duration on magnetostimulation thresholds.
  EU Saritas, PW Goodwill, SM Conolly.
  Med Phys. 2015 Jun;42(6):3005-12. doi:10.1118/1.4921209.
•  
• Usefulness of Magnetic Particle Imaging for Predicting the Therapeutic Effect of Magnetic Hyperthermia.
  K Murase, M Aoki, N Banura, K Nishimoto, A Mimura, T Kuboyabu, I Yabata.
  Open Journal of Medical Imaging. 2015 May 15;5(2):85-99. doi:10.4236/ojmi.2015.52013.

2013

•  
• Twenty-fold acceleration of 3D projection reconstruction MPI.
  J Konkle, PW Goodwill, EU Saritas, B Zheng, K Lu, SM Conolly.
  Biomed Tech (Berl). 2013 Dec;58(6):565-76. doi:10.1515/bmt-2012-0062.
•  
• Magnetostimulation Limits in Magnetic Particle Imaging.
  EU Saritas, PW Goodwill, GZ Zhang, SM Conolly.
  IEEE Trans Med Imaging. 2013 Sep;32(9):1600-10. doi:10.1109/TMI.2013.2260764.
•  
• Linearity and Shift-Invariance For Quantitative Magnetic Particle Imaging.
  K Lu, PW Goodwill, EU Saritas, B Zheng, SM Conolly.
  IEEE Trans Med Imaging. 2013 Sep;32(9):1565-75. doi:10.1109/TMI.2013.2257177.
•  
• Magnetic particle imaging (MPI) for NMR and MRI researchers
  EU Saritas, PW Goodwill, LR Croft, JJ Konkle, K Lu, B Zheng, SM Conolly
  J Magn Reson. 2013 Apr;229:116-26. doi:10.1016/j.jmr.2012.11.029.
•  
• Projection Reconstruction Magnetic Particle Imaging
  J Konkle, PW Goodwill, OM Carrasco-Zevallos, SM Conolly
  IEEE Trans Med Imaging. 2013 Feb;32(2):338-47. doi:10.1109/TMI.2012.2227121.

2012

•  
• Relaxation in X-Space Magnetic Particle Imaging.
  LR Croft, PW Goodwill, SM Conolly.
  IEEE Trans Med Imaging. 2012 Dec;31(12):2335-42. doi:10.1109/TMI.2012.2217979.
•  
• X-space MPI: Magnetic Nanoparticles for Safe Medical Imaging.
  PW Goodwill, EU Saritas, LR Croft, TN Kim, KM Krishnan, DV Schaffer, SM Conolly.
  Adv Mater. 2012 Jul 24;24(28):3870-7. doi:10.1002/adma.201200221.
•  
• Projection X-Space Magnetic Particle Imaging.
  PW Goodwill, J Konkle, B Zheng, SM Conolly.
  IEEE Trans Med Imaging. 2012 May;31(5):1076-85. doi:10.1109/TMI.2012.2185247.
•  
• An X-Space Magnetic Particle Imaging Scanner
  PW Goodwill, K Lu, B Zheng, SM Conolly
  Rev Sci Instrum. 2012 Mar;83(3):033708. doi:10.1063/1.3694534.

2011

•  
• Multidimensional X-Space Magnetic Particle Imaging.
  PW Goodwill, SM Conolly.
  IEEE Trans Med Imaging. 2011 Sep;30(9):1581-90. doi:10.1109/TMI.2011.2125982.
•  
• Ferrohydrodynamic Relaxometry for Magnetic Particle Imaging.
  PW Goodwill, A Tamrazian, LR Croft, CD Lu, EM Johnson, R Pidaparthi, RM Ferguson, AP Khandhar, KM Krishnan, SM Conolly.
  Applied Physics Letters. 2011 Jun 27;98(26):262502. doi:10.1063/1.3604009
•  
• First phantom and in vivo MPI images with an extended field of view.
  I Schmale, J Rahmer, B Gleich, J Kanzenbach, JD Schmidt, C Bontus, O Woywode, J Borgert.
  Proceedings of SPIE. 2011 Mar 9;7965:796510. doi:10.1117/12.877339.
•  
• Optimizing magnetite nanoparticles for mass sensitivity in magnetic particle imaging
  RM Ferguson, KR Minard, AP Khandhar, KM Krishnan
  Med Phys. 2011 Mar;38(3):1619-26. doi:10.1118/1.3554646.

2010

•  
• The X-space formulation of the magnetic particle imaging process: 1-D signal, resolution, bandwidth, SNR, SAR, and magnetostimulation.
  PW Goodwill, SM Conolly.
  IEEE Trans Med Imaging. 2010 Nov;29(11):1851-9. doi:10.1109/TMI.2010.2052284.

2009

•  
• Narrowband Magnetic Particle Imaging.
  PW Goodwill, G Scott, P Stang, SM Conolly.
  IEEE Trans Med Imaging. 2009 Aug;28(8):1231-7. doi:10.1109/TMI.2009.2013849.
•  
• Optimization of nanoparticle core size for magnetic particle imaging.
  RM Ferguson, KR Minard, KM Krishnan.
  J Magn Magn Mater. 2009;321(10):1548-1551. doi:10.1016/j.jmmm.2009.02.083.
•  
• Signal encoding in magnetic particle imaging: properties of the system function.
  J Rahmer, J Weizenecker, B Gleich, J Borgert.
  BMC Med Imaging. 2009 Apr 1;9:4. doi:10.1186/1471-2342-9-4.
•  
• Three-dimensional real-time in vivo magnetic particle imaging.
  J Weizenecker, B Gleich, J Rahmer, H Dahnke, J Borgert.
  Phys Med Biol. 2009 Mar 7;54(5):L1-L10. doi:10.1088/0031-9155/54/5/L01.

2005

•  
• Tomographic imaging using the nonlinear response of magnetic particles.
  B Gleich, J Weizenecker.
  Nature. 2005 Jun 30;435(7046):1214-7. doi:10.1038/nature03808.

Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
Rameriz A, Bhat R, Sahay D, et al.
BMC Cancer volume 19, Article number: 220 (2019)
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PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells
Kamal M, Saremi S, Klotz R, et al.
SciRep. 2019; 9(17470): 1-10.
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Validation Studies for Single Circulating Trophoblast Genetic Testing as a Form of Noninvasive Prenatal Diagnosis
Vossaert L, Wang Q, Salman R, et al.
AJHG. 2019; 105: 1-12
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A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples
Bailey-Hytholt C, Sayeed S, Kraus M, et al.
SciRep. 2019; 9(12115): 1-10.
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The RareCyte® Platform for Next-Generation Analysis of Circulating Tumor Cells
Kaldjian, E, Ramirez A, Sun Y, et al.
Cytometry Part A. 2018; 93A: 1220-1225.
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Reliable detection of subchromosomal deletions and duplications using cell-based noninvasive prenatal testing
Vossaert L, Wang Q, Salman R, et al.
Prenat Diagn. 2018; 38: 1069-1078.
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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Lin J, Izar B, Wang S, et al.
Elife. 2018; e31657: 1-46.
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Prostate cancer disseminated tumor cells are rarely detected in the bone marrow of patients with localized disease undergoing radical prostatectomy across multiple rare cell detection platforms
Chalfin H, Glavaris S, Malihi P, et al.
J Urol. 2018; 199(6): 1494-1501.
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A distributed network for intensive longitudinal monitoring in metastatic triple-negative breast cancer
Blau C, Ramirez A, Blau S, et al.
J Natl Compr Canc Netw. 2016; 14(1): 8-17.
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Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing
Breman A, Chow J, U’Ren L, et al.
Prenat Diagn. 2016; 36(11): 1009-1019.
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Nucleolin staining may aid in the identification of circulating prostate cancer cells
Chalfin H, Verdone, V, van der Toom E, Glavaris S, Gorin M, Pienta K.
Clin Genitourin Cancer. 2016; 15(3): 477-481.
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High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
Campton D, Ramirez A, Nordberg J, et al.
BMC Cancer. 2015; 15(360): 1-13.
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Select Posters

Sensitive Detection and Quantification of CAR-T Cells in Treated Patients
Presented by Crown Bio at AACR 2019
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Pick-Seq®: Spatial tissue analysis via multi‑parameter imaging and RNA sequencing of micro‑regions
Presented at SITC 2019
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Multiplex Immunofluorescence Staining, Whole Slide Imaging, and Spatial Phenotyping of T cell Exhaustion, Regulatory T cells, and Myeloid Derived Suppressor Cells in Tumor FFPE Samples
Presented at SITC 2019
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Amplicon-based targeted sequencing of single circulating tumor cells
Presented at AMP 2019
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Custom biomarker investigation of circulating tumor cells using RarePlex® Developer Kits
Presented at ACTC 2019
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Identification, retrieval, and RNA sequencing of single rare antigen-specific T cells from circulation using the RareCyte®platform Presented at AACR 2019
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Targeted single cell DNA sequencing without prior whole genome amplification for mutational analysis of circulating tumor cells
Presented at AACR 2019
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TCR sequencing from tissue micro-regions and single cells utilizing RareCyte® CytePicker® and Archer® Immunoverse™ technologies 
Presented at AACR 2019
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Single cell molecular characterization and PD-L1 expression analysis of model CTC using the RareCyte platform
Presented at TriCon 2019
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Multiparameter tissue section imaging and retrieval of image-defined micro-regions for RNA sequencing using the RareCyte platform
Presented at TriCon 2019
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Simultaneous assessment of PD-L1 and IRF1 expression on breast cancer circulating tumor cells
Presented at AACR 2018
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Increased phenotypic depth for automated visual identification of biomarkers on circulating tumor cells by cocktailing epithelial markers EpCAM and cytokeratin
Presented at AACR 2018 
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Development of a multi-parameter immunofluorescence assay for identification of circulating tumor cells with epithelial-mesenchymal phenotype
Presented at AACR 2018 
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Development of a multi-parameter immunofluorescence assay for simultaneous detection of androgen receptor and androgen receptor variant 7 in prostate cancer circulating tumor cells
Presented at AACR 2018 
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Detection and retrieval of multiple myeloma cells with single cell molecular confirmation from peripheral blood by multi-parameter immunofluorescence, automated scanning and image analysis
Presented at AACR 2018 
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Novel multi-parameter assays for investigational phenotyping of circulating tumor cells
Presented at Next Gen Dx 2018
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